Hepatoprotective effect of food preservatives (butylated hydroxyanisole, butylated hydroxytoluene) on carbon tetrachloride-induced hepatotoxicity in rat

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Hepatoprotective effect of food preservatives (butylated hydroxyanisole, butylated hydroxytoluene) on carbon tetrachloride-induced hepatotoxicity in rat

Carbon tetrachloride (CCl4), a hepatotoxic agent is widely used to study the toxic mechanisms in experimental animals. This study was carried out to establish the hepatoprotective measures of food preservative antioxidants butylated hydroxyanisole and butylated hydroxytolune (BHA, BHT) when mixed with food towards carbon tetrachloride (CCl4) intoxication (230 mg/ kg b wt/rat/day) in rat. Bioche...

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Antioxidant Properties of Thymol and Butylated Hydroxytoluene in Carbon Tetrachloride – Induced Mice Liver Injury

Thymol and Butylated hydroxytoluene (BHT) were tested for their ability to inhibit carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. To achieve this purpose, four groups of mice were tested, GP I: Animals served as normal control, GP II: Animals injected i.p. with a single dose of CCl4 (0.5 ml/kg B.W), GP III and IV: Animals pretreated by oral administration of thymol or BHT...

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Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat

Objective: The present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Male Wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina ...

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Different Modifying Response of Butylated Hydroxyanisole, Butylated Hydroxytoluene, and Other Antioxidants in A'jjV-Dibutylnitrosamine Esophagus and Forestomach Carcinogenesis of Rats1

The modifying effects of antioxidants were examined in a carcinogenesis system after \, V-ililnilvlniinisamiiic treatment. Male F344 rats were given 0.05% V, Vdilnilylnhrosarnmiin their drinking water for 4 wk and then treated with basal diet containing 2% butylated hydroxyanisole (BHA), 1% butylated hydroxytoluene (BHT) with 7 ppm vitamin K, 0.8% ethoxyquin, 5% sodium L-ascorbate, 57. sodium e...

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Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and women aged 55 to 69 years. A semi-quantitative food f...

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ژورنال

عنوان ژورنال: Toxicology Reports

سال: 2018

ISSN: 2214-7500

DOI: 10.1016/j.toxrep.2017.12.009